Version 5.4
Bos taurus Gene: GABARAP
Summary
InnateDB Gene IDBG-634658.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABARAP
Gene Name Gamma-aminobutyric acid receptor-associated protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014883
Encoded Proteins
IDBP-686439
Gamma-aminobutyric acid receptor-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23427251
[Mus musculus] Gabarap deficient mice are more susceptible to sepsis due to enhanced inflammasome activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170296:
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:27586886-27588815
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019814 ENSBTAP00000019814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Predicted by orthology
Total 76 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0048487 beta-tubulin binding
GO:0050811 GABA receptor binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000226 microtubule cytoskeleton organization
GO:0006810 transport
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0015031 protein transport
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagic vacuole
GO:0005790 smooth endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000170296
View Gene Order
ENSMUSG00000018567
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.49217
RefSeq NM_001034048
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca