Version 5.4
Bos taurus Protein: PLA2G1B
Summary
InnateDB Protein IDBP-686541.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G1B
Protein Name Phospholipase A2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000037960
InnateDB Gene IDBG-634759 (PLA2G1B)
Protein Structure
UniProt Annotation
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Subcellular Localization Secreted. Note=secreted from pancreatic acinar cells in its inactive form. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001211 Phospholipase A2
IPR016090 Phospholipase A2 domain
PFAM PF05826
PF00068
PRINTS PR00389
PIRSF
SMART SM00085
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00593
PhosphoSite PhosphoSite-
TrEMBL G3X7M0
UniProt Splice Variant
Entrez Gene 282457
UniGene Bt.4439
RefSeq NP_777071
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045448 Y00120
GenPept CAA68303

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca