Version 5.4
Bos taurus Gene: PLA2G1B
Summary
InnateDB Gene IDBG-634759.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G1B
Gene Name Phospholipase A2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000026732
Encoded Proteins
IDBP-686541
Phospholipase A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170890:
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64899652-64902627
Strand Reverse strand
Band
Transcripts
ENSBTAT00000038144 ENSBTAP00000037960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000170890
View Gene Order
ENSMUSG00000029522
View Gene Order
Pathways
NETPATH
REACTOME
REACT_211382
Synthesis of PA pathway
REACT_205553
Acyl chain remodelling of PC pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_206203
Acyl chain remodelling of PI pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_224920
Acyl chain remodelling of PS pathway
REACT_218329
Phospholipid metabolism pathway
REACT_204784
Acyl chain remodelling of PE pathway
REACT_207095
Acyl chain remodelling of PG pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_121384
Acyl chain remodelling of PS pathway
REACT_120906
Synthesis of PA pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199039
Acyl chain remodelling of PG pathway
REACT_199030
Acyl chain remodelling of PS pathway
REACT_199027
Acyl chain remodelling of PE pathway
REACT_199024
Acyl chain remodelling of PI pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04975
Fat digestion and absorption pathway
hsa04972
Pancreatic secretion pathway
mmu00564
Glycerophospholipid metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00591
Linoleic acid metabolism pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04972
Pancreatic secretion pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4439
RefSeq NM_174646
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca