Bos taurus Protein: NUBP2
Summary
InnateDB Protein IDBP-686626.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUBP2
Protein Name Cytosolic Fe-S cluster assembly factor NUBP2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022029
InnateDB Gene IDBG-634831 (NUBP2)
Protein Structure
UniProt Annotation
Function Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. {ECO:0000255HAMAP-Rule:MF_03039}.
Subcellular Localization Nucleus {ECO:0000255HAMAP-Rule:MF_03039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP-Rule:MF_03039}. Note=Enriched at the centrosomes during mitosis. {ECO:0000255HAMAP-Rule:MF_03039}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0031616 spindle pole centrosome
Protein Structure and Domains
PDB ID
InterPro IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR005129 ArgK protein
IPR015223 ATPase MipZ/NubP2/Cfd1
IPR019591 Mrp/NBP35 ATP-binding protein
IPR025723 Anion-transporting ATPase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01656
PF03308
PF09140
PF10609
PF02374
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHY6
PhosphoSite PhosphoSite-
TrEMBL M5FK02
UniProt Splice Variant
Entrez Gene 515660
UniGene Bt.2198
RefSeq NP_001029677
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104526 GJ062847
GenPept AAI04527 DAA15585