Version 5.4
Bos taurus Protein: TRPC5
Summary
InnateDB Protein IDBP-686634.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPC5
Protein Name Short transient receptor potential channel 5
Synonyms trp;
Species Bos taurus
Ensembl Protein ENSBTAP00000013270
InnateDB Gene IDBG-634841 (TRPC5)
Protein Structure
UniProt Annotation
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034704 calcium channel complex
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005461 Transient receptor potential channel, canonical 5
IPR005821 Ion transport domain
IPR013555 Transient receptor ion channel domain
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF00520
PF08344
PF11929
PF12796
PRINTS PR01415
PR01097
PR01646
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9MYV9
PhosphoSite PhosphoSite-
TrEMBL F1MTE6
UniProt Splice Variant
Entrez Gene 407103
UniGene Bt.29713
RefSeq NP_001160046
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ271070 DAAA02072068 DAAA02072069 DAAA02072070 DAAA02072071 DAAA02072072 DAAA02072073 DAAA02072074 DAAA02072075 DAAA02072076 DAAA02072077 DAAA02072078 DAAA02072079 DAAA02072080 DAAA02072081 DAAA02072082 DAAA02072083 DAAA02072084 DAAA02072085 DAAA02072086
GenPept CAC01678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca