InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RECQL5

Summary

InnateDB Protein

IDBP-68672.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RECQL5

Protein Name

RecQ protein-like 5

Synonyms

RECQ5;

Species

Homo sapiens

Ensembl Protein

ENSP00000341983

InnateDB Gene

IDBG-68668 (RECQL5)

Protein Structure

UniProt Annotation

Function

Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. {ECO:0000269PubMed:20231364, ECO:0000269PubMed:20348101, ECO:0000269PubMed:20643585, ECO:0000269PubMed:22013166, ECO:0000269PubMed:22973052, ECO:0000269PubMed:23715498, ECO:0000269PubMed:23748380}.

Subcellular Localization

Isoform Beta: Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks.Isoform Alpha: Cytoplasm.Isoform Gamma: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007067	mitotic nuclear division
GO:0032508	DNA duplex unwinding
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0051304	chromosome separation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94762