InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RECQL5

Summary

InnateDB Gene

IDBG-68668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RECQL5

Gene Name

RecQ protein-like 5

Synonyms

RECQ5

Species

Homo sapiens

Ensembl Gene

ENSG00000108469

Encoded Proteins

IDBP-68670

RecQ protein-like 5

IDBP-68672

RecQ protein-like 5

IDBP-384428

RecQ protein-like 5

IDBP-384433

RecQ protein-like 5

IDBP-764270

IDBP-759404

IDBP-762161

IDBP-761933

IDBP-764162

IDBP-764815

IDBP-762940

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:75626845-75667189

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000317905	ENSP00000317636
ENST00000340830	ENSP00000341983
ENST00000423245	ENSP00000394820
ENST00000443199
ENST00000420326	ENSP00000414933
ENST00000580707	ENSP00000463701
ENST00000578201	ENSP00000463099
ENST00000581827
ENST00000585205
ENST00000582464	ENSP00000462077
ENST00000579265
ENST00000578865
ENST00000580078	ENSP00000462547
ENST00000583673
ENST00000579274
ENST00000579739
ENST00000582548	ENSP00000462291
ENST00000584999	ENSP00000462248
ENST00000581825	ENSP00000462678

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007067	mitotic nuclear division
GO:0032508	DNA duplex unwinding
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0051304	chromosome separation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020752

View Gene Order

ENSBTAG00000011715

Not yet available

Cross-References

SwissProt

O94762

TrEMBL

A0A024R8S8

UniProt Splice Variant

Entrez Gene

9400

UniGene

Hs.632229 Hs.674209 Hs.689672

RefSeq

NM_001003715 NM_001003716 NM_004259 XM_005257823

HUGO

HGNC:9950

OMIM

603781

CCDS

CCDS32735 CCDS42380 CCDS45777

HPRD

04806

IMGT

EMBL

AB006533 AB042823 AB042824 AB042825 AF135183 AL136869 BC016911 CH471099

GenPept

AAD43061 AAD43062 AAH16911 BAA74454 BAA95952 BAA95953 BAA95954 CAB66803 EAW89294 EAW89295

RNA Seq Atlas

9400