InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IMPDH1

Summary

InnateDB Protein

IDBP-686865.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMPDH1

Protein Name

inosine-5'-monophosphate dehydrogenase 1

Synonyms

IMPD 1; IMPDH 1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000374

InnateDB Gene

IDBG-635060 (IMPDH1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000255HAMAP- Rule:MF_03156}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03156}. Nucleus {ECO:0000255HAMAP-Rule:MF_03156}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018580	nitronate monooxygenase activity
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0046651	lymphocyte proliferation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000262 FMN-dependent dehydrogenase
IPR000644 CBS domain
IPR001093 IMP dehydrogenase/GMP reductase
IPR004136 2-nitropropane dioxygenase, NPD
IPR005990 Inosine-5\'-monophosphate dehydrogenase

PFAM

PF01070
PF00571
PF00478
PF03060

PRINTS

PIRSF

PIRSF000130

SMART

SM00116

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A0JNA3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504305

UniGene

Bt.29279

RefSeq

NP_001071309

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126584 DAAA02011497

GenPept

AAI26585