InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IMPDH1

Summary

InnateDB Gene

IDBG-635060.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMPDH1

Gene Name

Inosine-5'-monophosphate dehydrogenase 1

Synonyms

IMPD 1; IMPDH 1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000296

Encoded Proteins

IDBP-686865

inosine-5'-monophosphate dehydrogenase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106348:
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5\'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:93382312-93399661

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000374

ENSBTAP00000000374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018580	nitronate monooxygenase activity
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0046651	lymphocyte proliferation
GO:0055114	oxidation-reduction process