InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRPV4

Summary

InnateDB Protein

IDBP-686879.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV4

Protein Name

transient receptor potential cation channel, subfamily V, member 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000034

InnateDB Gene

IDBG-635063 (TRPV4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005034	osmosensor activity
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006970	response to osmotic stress
GO:0007043	cell-cell junction assembly
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007231	osmosensory signaling pathway
GO:0030103	vasopressin secretion
GO:0034605	cellular response to heat
GO:0042538	hyperosmotic salinity response
GO:0047484	regulation of response to osmotic stress
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0071470	cellular response to osmotic stress
GO:0071476	cellular hypotonic response

Cellular Component

GO:0005912	adherens junction
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR005821 Ion transport domain
IPR008347 Transient receptor potential channel, vanilloid 1-4
IPR008348 Transient receptor potential channel, vanilloid 4
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF11929
PF12796

PRINTS

PR01415
PR01768
PR01769

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt