InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRPV4

Summary

InnateDB Gene

IDBG-635063.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV4

Gene Name

transient receptor potential cation channel subfamily V member 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000031

Encoded Proteins

IDBP-686879

transient receptor potential cation channel, subfamily V, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111199:
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:65678454-65699847

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000034

ENSBTAP00000000034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005034	osmosensor activity
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006970	response to osmotic stress
GO:0007043	cell-cell junction assembly
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007231	osmosensory signaling pathway
GO:0030103	vasopressin secretion
GO:0034605	cellular response to heat
GO:0042538	hyperosmotic salinity response
GO:0047484	regulation of response to osmotic stress
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0071470	cellular response to osmotic stress
GO:0071476	cellular hypotonic response