Version 5.4
Bos taurus Protein: CSF1
Summary
InnateDB Protein IDBP-687071.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF1
Protein Name macrophage colony-stimulating factor 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000353
InnateDB Gene IDBG-635251 (CSF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002158 osteoclast proliferation
GO:0003006 developmental process involved in reproduction
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0040018 positive regulation of multicellular organism growth
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth
GO:0045651 positive regulation of macrophage differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048873 homeostasis of number of cells within a tissue
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060611 mammary gland fat development
GO:0060763 mammary duct terminal end bud growth
Cellular Component
GO:0005615 extracellular space
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008001 Macrophage colony stimulating factor-1
IPR009079 Four-helical cytokine-like, core
PFAM PF05337
PRINTS
PIRSF PIRSF001948
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MGS9
UniProt Splice Variant
Entrez Gene 281094
UniGene Bt.366
RefSeq NP_776451
HUGO HGNC:2432
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007561
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca