InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CSF1

Summary

InnateDB Gene

IDBG-635251.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF1

Gene Name

macrophage colony-stimulating factor 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000283

Encoded Proteins

IDBP-687071

macrophage colony-stimulating factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184371:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:33607139-33621030

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000353

ENSBTAP00000000353

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005157	macrophage colony-stimulating factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0002158	osteoclast proliferation
GO:0003006	developmental process involved in reproduction
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0030278	regulation of ossification
GO:0030316	osteoclast differentiation
GO:0030335	positive regulation of cell migration
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0040018	positive regulation of multicellular organism growth
GO:0042488	positive regulation of odontogenesis of dentin-containing tooth
GO:0045651	positive regulation of macrophage differentiation
GO:0045657	positive regulation of monocyte differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048873	homeostasis of number of cells within a tissue
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060611	mammary gland fat development
GO:0060763	mammary duct terminal end bud growth

Cellular Component

GO:0005615	extracellular space
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome