InnateDB Protein
|
IDBP-68714.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TRA2B
|
Protein Name
|
transformer 2 beta homolog (Drosophila)
|
Synonyms
|
Htra2-beta; PPP1R156; SFRS10; SRFS10; TRA2-BETA; TRAN2B;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000343857
|
InnateDB Gene
|
IDBG-68708 (TRA2B)
|
Protein Structure
|
|
Function |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA. {ECO:0000269PubMed:12165565, ECO:0000269PubMed:12761049, ECO:0000269PubMed:15009664, ECO:0000269PubMed:9546399}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:9212162, ECO:0000269PubMed:9546399}.
|
Disease Associations |
|
Tissue Specificity |
Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. {ECO:0000269PubMed:9790768}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
78
[view]
|
Protein-Protein |
78
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0000375
|
RNA splicing, via transesterification reactions
|
GO:0000381
|
regulation of alternative mRNA splicing, via spliceosome
|
GO:0000398
|
mRNA splicing, via spliceosome
|
GO:0048026
|
positive regulation of mRNA splicing, via spliceosome
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P62995
|
PhosphoSite |
PhosphoSite-P62995
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
6434
|
UniGene |
Hs.718147
|
RefSeq |
|
HUGO |
HGNC:10781
|
OMIM |
602719
|
CCDS |
|
HPRD |
04097
|
IMGT |
|
EMBL |
AF057159
AK301118
BC000160
BC000451
BC005898
CH471052
U61267
U68063
U87836
|
GenPept |
AAB08701
AAB69763
AAC28242
AAD19277
AAD19278
AAD19279
AAH00160
AAH00451
AAH05898
BAG62714
EAW78204
EAW78205
EAW78208
|
|
|