InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DYNLT1

Summary

InnateDB Protein

IDBP-687195.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNLT1

Protein Name

Dynein light chain Tctex-type 1

Synonyms

TCTEL1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005869

InnateDB Gene

IDBG-635357 (DYNLT1)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein (By similarity). {ECO:0000250}.Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor- independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus {ECO:0000269PubMed:9677391}. Cytoplasm {ECO:0000269PubMed:9677391}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:9677391}. Note=Localizes to mitotic spindles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0043001	Golgi to plasma membrane protein transport
GO:0050768	negative regulation of neurogenesis
GO:0051301	cell division

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0030286	dynein complex

Protein Structure and Domains

PDB ID

InterPro

IPR005334 Tctex-1

PFAM

PF03645

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P63171

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282380

UniGene

Bt.64528

RefSeq

NP_777045

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF067370 BC108160

GenPept

AAC39268 AAI08161