InnateDB Protein
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IDBP-68728.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NCOA6
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Protein Name
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nuclear receptor coactivator 6
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Synonyms
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AIB3; ASC2; NRC; PRIP; RAP250; TRBP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363929
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InnateDB Gene
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IDBG-68724 (NCOA6)
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Protein Structure
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Function |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
119
[view]
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Protein-Protein |
118
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14686
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PhosphoSite |
PhosphoSite-Q14686
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23054
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UniGene |
Hs.606277
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RefSeq |
XP_005260405
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HUGO |
HGNC:15936
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OMIM |
605299
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CCDS |
CCDS13241
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HPRD |
05599
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IMGT |
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EMBL |
AF128458
AF171667
AF177388
AF208227
AF245115
AL109824
BC136272
CH471077
D80003
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GenPept |
AAF13595
AAF16403
AAF37003
AAF71829
AAF78480
AAI36273
BAA11498
CAB92721
EAW76254
EAW76255
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