InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CKB

Summary

InnateDB Protein

IDBP-687291.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKB

Protein Name

Creatine kinase B-type

Synonyms

B-CK;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000047181

InnateDB Gene

IDBG-635454 (CKB)

Protein Structure

UniProt Annotation

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004111	creatine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0007420	brain development
GO:0016310	phosphorylation
GO:0021762	substantia nigra development
GO:0030644	cellular chloride ion homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR022413 ATP:guanido phosphotransferase, N-terminal
IPR022414 ATP:guanido phosphotransferase, catalytic domain

PFAM

PF02807
PF00217

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EA61

PhosphoSite

PhosphoSite-

TrEMBL

Q9N1C7

UniProt Splice Variant

Entrez Gene

516210

UniGene

Bt.88935

RefSeq

NP_001015613

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF207866 BC102333 BT020708

GenPept

AAF67082 AAI02334 AAX08725