InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP6V0C

Summary

InnateDB Protein

IDBP-687369.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0C

Protein Name

V-type proton ATPase 16 kDa proteolipid subunit

Synonyms

PLP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000037385

InnateDB Gene

IDBG-635530 (ATP6V0C)

Protein Structure

UniProt Annotation

Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Vacuole membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0008152	metabolic process
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0030177	positive regulation of Wnt signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005773	vacuole
GO:0005774	vacuolar membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome