InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PLG

Summary

InnateDB Protein

IDBP-687460.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLG

Protein Name

plasminogen precursor

Synonyms

LPA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001674

InnateDB Gene

IDBG-635599 (PLG)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0019904	protein domain specific binding
GO:0034185	apolipoprotein binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0010812	negative regulation of cell-substrate adhesion
GO:0022617	extracellular matrix disassembly
GO:0042246	tissue regeneration
GO:0045445	myoblast differentiation
GO:0046716	muscle cell cellular homeostasis
GO:0051918	negative regulation of fibrinolysis
GO:0051919	positive regulation of fibrinolysis
GO:0060707	trophoblast giant cell differentiation
GO:0060716	labyrinthine layer blood vessel development
GO:0071674	mononuclear cell migration

Cellular Component

GO:0005615	extracellular space
GO:0009986	cell surface
GO:0019897	extrinsic component of plasma membrane
GO:0031232	extrinsic component of external side of plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR015420 Peptidase S1A, nudel
IPR023317 Peptidase S1A, plasmin

PFAM

PF00051
PF00089
PF00024
PF09342

PRINTS

PR00722

PIRSF

PIRSF001150

SMART

SM00130
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1B726

UniProt Splice Variant

Entrez Gene

280897

UniGene

Bt.306

RefSeq

NP_776376

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02027385

GenPept