Version 5.4
Bos taurus Gene: PLG
Summary
InnateDB Gene IDBG-635599.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLG
Gene Name plasminogen precursor
Synonyms LPA
Species Bos taurus
Ensembl Gene ENSBTAG00000001271
Encoded Proteins
IDBP-687456
plasminogen precursor
IDBP-687460
plasminogen precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21464960
[Homo sapiens] PLG is a serum protein that interacts with B. anthracis spores and cleaves complement 3 molecules, resulting in a decrease in macrophage phagocytosis.
PMID 21464960
[Mus musculus] Plg is a serum protein that interacts with B. anthracis spores and cleaves complement 3 molecules, resulting in a decrease in macrophage phagocytosis. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122194:
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:98016582-98064203
Strand Reverse strand
Band
Transcripts
ENSBTAT00000053284 ENSBTAP00000051417
ENSBTAT00000001674 ENSBTAP00000001674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0034185 apolipoprotein binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0010812 negative regulation of cell-substrate adhesion
GO:0022617 extracellular matrix disassembly
GO:0042246 tissue regeneration
GO:0045445 myoblast differentiation
GO:0046716 muscle cell cellular homeostasis
GO:0051918 negative regulation of fibrinolysis
GO:0051919 positive regulation of fibrinolysis
GO:0060707 trophoblast giant cell differentiation
GO:0060716 labyrinthine layer blood vessel development
GO:0071674 mononuclear cell migration
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0019897 extrinsic component of plasma membrane
GO:0031232 extrinsic component of external side of plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000122194
View Gene Order
ENSMUSG00000059481
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_641
Dissolution of Fibrin Clot pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_16888
Signaling by PDGF pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_267716
Orphan transporters pathway
REACT_17015
Metabolism of proteins pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_268398
Orphan transporters pathway
REACT_222614
LDL-mediated lipid transport pathway
REACT_199000
Activation of Matrix Metalloproteinases pathway
REACT_188937
Metabolism pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_235291
Dissolution of Fibrin Clot pathway
REACT_263353
Signaling by PDGF pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04610
Complement and coagulation cascades pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
p75ntrpathway
p75(NTR)-mediated signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
syndecan_4_pathway
Syndecan-4-mediated signaling events
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL A7E350 E1B726
UniProt Splice Variant
Entrez Gene 280897
UniGene Bt.306
RefSeq NM_173951 XM_005211084 XM_005211085 XM_005211086
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151718 DAAA02027385
GenPept AAI51719
RNA Seq Atlas 280897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca