Version 5.4
Bos taurus Protein: CITED1
Summary
InnateDB Protein IDBP-687548.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CITED1
Protein Name Cbp/p300-interacting transactivator 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055749
InnateDB Gene IDBG-635694 (CITED1)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
GO:0050693 LBD domain binding
GO:0070410 co-SMAD binding
Biological Process
GO:0001570 vasculogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007420 brain development
GO:0010628 positive regulation of gene expression
GO:0030154 cell differentiation
GO:0030318 melanocyte differentiation
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0034097 response to cytokine
GO:0034341 response to interferon-gamma
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043627 response to estrogen
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051591 response to cAMP
GO:0060395 SMAD protein signal transduction
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:0070555 response to interleukin-1
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070741 response to interleukin-6
GO:0071104 response to interleukin-9
GO:0071105 response to interleukin-11
GO:0071107 response to parathyroid hormone
GO:0071559 response to transforming growth factor beta
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007576 CITED
PFAM PF04487
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BDI3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282182
UniGene Bt.4437
RefSeq NP_776943
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF362075 BC102725
GenPept AAI02726 AAK27241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca