Version 5.4
Homo sapiens Protein: HIST1H1D
Summary
InnateDB Protein IDBP-68755.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1D
Protein Name histone cluster 1, H1d
Synonyms H1.3; H1D; H1F3; H1s-2;
Species Homo sapiens
Ensembl Protein ENSP00000244534
InnateDB Gene IDBG-68753 (HIST1H1D)
Protein Structure
UniProt Annotation
Function Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0016584 nucleosome positioning
Cellular Component
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
Protein Structure and Domains
PDB ID
InterPro IPR005818 Linker histone H1/H5, domain H15
IPR005819 Histone H5
PFAM PF00538
PRINTS PR00624
PIRSF
SMART SM00526
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16402
PhosphoSite PhosphoSite-P16402
TrEMBL
UniProt Splice Variant
Entrez Gene 3007
UniGene Hs.136857
RefSeq NP_005311
HUGO HGNC:4717
OMIM 142210
CCDS CCDS4597
HPRD 06764
IMGT
EMBL AF531303 AK312845 AL031777 BC104874 BC111971 CH471087 M60747
GenPept AAA63186 AAI04875 AAI11972 AAN06703 BAG35698 CAB39189 EAW55548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca