Version 5.4
Bos taurus Protein: APLF
Summary
InnateDB Protein IDBP-687558.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APLF
Protein Name Aprataxin and PNK-like factor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055056
InnateDB Gene IDBG-635685 (APLF)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520 endodeoxyribonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0000012 single strand break repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0045191 regulation of isotype switching
GO:0051106 positive regulation of DNA ligation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0035861 site of double-strand break
Protein Structure and Domains
PDB ID
InterPro IPR008984 SMAD/FHA domain
IPR019406 Zinc finger, C2H2, APLF-like
PFAM PF10283
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3MZQ3
UniProt Splice Variant
Entrez Gene 507989
UniGene Bt.63859
RefSeq XP_005212902
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031513
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca