Version 5.4
Bos taurus Gene: APLF
Summary
InnateDB Gene IDBG-635685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APLF
Gene Name Aprataxin and PNK-like factor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018401
Encoded Proteins
IDBP-687558
Aprataxin and PNK-like factor
IDBP-687561
Aprataxin and PNK-like factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169621:
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66840544-66933742
Strand Forward strand
Band
Transcripts
ENSBTAT00000063133 ENSBTAP00000055056
ENSBTAT00000044615 ENSBTAP00000042099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520 endodeoxyribonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0000012 single strand break repair
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0045191 regulation of isotype switching
GO:0051106 positive regulation of DNA ligation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0035861 site of double-strand break
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169621
View Gene Order
ENSMUSG00000030051
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.63859
RefSeq NM_001077874 XM_005212845 XM_005212846
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca