InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: APLF

Summary

InnateDB Protein

IDBP-687561.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APLF

Protein Name

Aprataxin and PNK-like factor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000042099

InnateDB Gene

IDBG-635685 (APLF)

Protein Structure

UniProt Annotation

Function

Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520	endodeoxyribonuclease activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0016829	lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0000012	single strand break repair
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR008984 SMAD/FHA domain
IPR019406 Zinc finger, C2H2, APLF-like

PFAM

PF10283

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A0JNH9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

507989

UniGene

Bt.63859

RefSeq

NP_001071342

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126691

GenPept

AAI26692