InnateDB Protein
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IDBP-687599.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FBLIM1
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Protein Name
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Filamin-binding LIM protein 1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000024926
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InnateDB Gene
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IDBG-635735 (FBLIM1)
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Protein Structure
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Function |
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q1JQB5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
767833
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UniGene |
Bt.2860
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RefSeq |
NP_001070423
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC116079
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GenPept |
AAI16080
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