Version 5.4
Bos taurus Gene: FBLIM1
Summary
InnateDB Gene IDBG-635735.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBLIM1
Gene Name Filamin-binding LIM protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018725
Encoded Proteins
IDBP-687599
Filamin-binding LIM protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162458:
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:53027481-53049143
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024926 ENSBTAP00000024926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0031005 filamin binding
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0008360 regulation of cell shape
GO:0016337 single organismal cell-cell adhesion
GO:0033623 regulation of integrin activation
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162458
View Gene Order
ENSMUSG00000006219
View Gene Order
Pathways
NETPATH
REACTOME
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_213279
Cell-extracellular matrix interactions pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q1JQB5
TrEMBL
UniProt Splice Variant
Entrez Gene 767833
UniGene Bt.2860
RefSeq NM_001076955 XM_005217135 XM_005217136 XM_005217137
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116079
GenPept AAI16080
RNA Seq Atlas 767833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca