InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: B4GALT1

Summary

InnateDB Protein

IDBP-687616.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B4GALT1

Protein Name

Beta-1,4-galactosyltransferase 1Lactose synthase A proteinN-acetyllactosamine synthaseBeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferaseBeta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferaseProcessed beta-1,4-galactosyltransferase 1

Synonyms

GGTB2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020286

InnateDB Gene

IDBG-635744 (B4GALT1)

Protein Structure

UniProt Annotation

Function

The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.

Subcellular Localization

Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Note=Found in trans cisternae of Golgi.Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi.Processed beta-1,4-galactosyltransferase 1: Secreted. Note=Soluble form found in body fluids.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003945	N-acetyllactosamine synthase activity
GO:0004461	lactose synthase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008378	galactosyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0030145	manganese ion binding
GO:0035250	UDP-galactosyltransferase activity
GO:0042803	protein homodimerization activity
GO:0043014	alpha-tubulin binding
GO:0046872	metal ion binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0002064	epithelial cell development
GO:0002526	acute inflammatory response
GO:0005975	carbohydrate metabolic process
GO:0005989	lactose biosynthetic process
GO:0006012	galactose metabolic process
GO:0006486	protein glycosylation
GO:0006487	protein N-linked glycosylation
GO:0007155	cell adhesion
GO:0007339	binding of sperm to zona pellucida
GO:0007341	penetration of zona pellucida
GO:0008285	negative regulation of cell proliferation
GO:0009101	glycoprotein biosynthetic process
GO:0009312	oligosaccharide biosynthetic process
GO:0030198	extracellular matrix organization
GO:0030879	mammary gland development
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045136	development of secondary sexual characteristics
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050900	leukocyte migration
GO:0051270	regulation of cellular component movement
GO:0060046	regulation of acrosome reaction
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060055	angiogenesis involved in wound healing
GO:0060058	positive regulation of apoptotic process involved in mammary gland involution

Cellular Component

GO:0000138	Golgi trans cisterna
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030057	desmosome
GO:0030112	glycocalyx
GO:0031526	brush border membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003859 Beta-1,4-galactosyltransferase
IPR027791 Galactosyltransferase, C-terminal
IPR029044 Nucleotide-diphospho-sugar transferases

PFAM

PF02709

PRINTS

PR02050

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08037

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281781

UniGene

Bt.75970

RefSeq

NP_803478

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF515786 BC120415 J05217 M13214 M25398 X14558

GenPept

AAA30533 AAA30534 AAA30559 AAI20416 AAM54035 CAA32695