Version 5.4
Bos taurus Protein: ADSSL1
Summary
InnateDB Protein IDBP-687625.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADSSL1
Protein Name Adenylosuccinate synthetase isozyme 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000041803
InnateDB Gene IDBG-635746 (ADSSL1)
Protein Structure
UniProt Annotation
Function Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03126}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004019 adenylosuccinate synthase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006167 AMP biosynthetic process
GO:0044208 'de novo' AMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001114 Adenylosuccinate synthetase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00709
PRINTS
PIRSF
SMART SM00788
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5PJR4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 784089
UniGene Bt.16782
RefSeq NP_001092662
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142211
GenPept AAI42212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca