Bos taurus Protein: AQP3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-687665.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | AQP3 | ||||||||||||||
Protein Name | Aquaporin-3 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000011196 | ||||||||||||||
InnateDB Gene | IDBG-635798 (AQP3) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR000425
Major intrinsic protein IPR023271 Aquaporin-like IPR023275 Aquaporin 3 |
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PFAM |
PF00230
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PRINTS |
PR00783
PR02015 |
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PIRSF | |||||||||||||||
SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q08DE6 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 780866 | ||||||||||||||
UniGene | Bt.53350 | ||||||||||||||
RefSeq | NP_001073262 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC123791 | ||||||||||||||
GenPept | AAI23792 | ||||||||||||||