Version 5.4
Bos taurus Protein: MTPN
Summary
InnateDB Protein IDBP-687672.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTPN
Protein Name Myotrophin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010269
InnateDB Gene IDBG-635804 (MTPN)
Protein Structure
UniProt Annotation
Function Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010557 positive regulation of macromolecule biosynthetic process
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016049 cell growth
GO:0030307 positive regulation of cell growth
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051247 positive regulation of protein metabolic process
GO:2000812 regulation of barbed-end actin filament capping
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008290 F-actin capping protein complex
GO:0030424 axon
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0F7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 541099
UniGene Bt.63717
RefSeq NP_976238
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102413
GenPept AAI02414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca