InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MTPN

Summary

InnateDB Gene

IDBG-635804.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTPN

Gene Name

Myotrophin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007806

Encoded Proteins

IDBP-687672

Myotrophin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105887:
A bi-cistronic transcript encodes the products of both the myotrophin and leucine zipper protein 6 genes, which are located on chromosome 7. A cryptic ORF at the 3' end of the myotrophin transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008] The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:100550308-100626568

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010269

ENSBTAP00000010269

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0010557	positive regulation of macromolecule biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016049	cell growth
GO:0030307	positive regulation of cell growth
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051247	positive regulation of protein metabolic process
GO:2000812	regulation of barbed-end actin filament capping

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008290	F-actin capping protein complex
GO:0030424	axon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000105887

View Gene Order

ENSMUSG00000029840

View Gene Order

Cross-References

SwissProt

Q3T0F7

TrEMBL

UniProt Splice Variant

Entrez Gene

541099

UniGene

Bt.63717

RefSeq

NM_203362

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102413

GenPept

AAI02414

RNA Seq Atlas

541099