InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC42EP5

Summary

InnateDB Protein

IDBP-68768.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC42EP5

Protein Name

CDC42 effector protein (Rho GTPase binding) 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301200

InnateDB Gene

IDBG-68766 (CDC42EP5)

Protein Structure

UniProt Annotation

Function

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity). {ECO:0000250}.

Subcellular Localization

Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017049	GTP-Rho binding

Biological Process

GO:0007254	JNK cascade
GO:0007266	Rho protein signal transduction
GO:0008360	regulation of cell shape
GO:0030838	positive regulation of actin filament polymerization
GO:0031274	positive regulation of pseudopodium assembly