Version 5.4
Homo sapiens Gene: CDC42EP5
Summary
InnateDB Gene IDBG-68766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP5
Gene Name CDC42 effector protein (Rho GTPase binding) 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167617
Encoded Proteins
IDBP-68768
CDC42 effector protein (Rho GTPase binding) 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54465026-54473264
Strand Reverse strand
Band q13.42
Transcripts
ENST00000301200 ENSP00000301200
ENST00000472703
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0007254 JNK cascade
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063838
View Gene Order
ENSBTAG00000045989
Not yet available
Cross-References
SwissProt Q6NZY7
TrEMBL
UniProt Splice Variant
Entrez Gene 148170
UniGene
RefSeq NM_145057
HUGO HGNC:17408
OMIM 609171
CCDS CCDS12896
HPRD 13023
IMGT
EMBL BC024327 BC065910 CH471135 CU207370 CU467002
GenPept AAH24327 AAH65910 CAQ08958 CAQ52436 EAW72252
RNA Seq Atlas 148170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca