InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CASP9

Summary

InnateDB Protein

IDBP-687742.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP9

Protein Name

caspase 9, apoptosis-related cysteine peptidase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003205

InnateDB Gene

IDBG-635833 (CASP9)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0034644	cellular response to UV
GO:0042770	signal transduction in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0071549	cellular response to dexamethasone stimulus
GO:2001020	regulation of response to DNA damage stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043293	apoptosome

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References