Version 5.4
| Bos taurus Gene: CASP9 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||||
| InnateDB Gene | IDBG-635833.3 | ||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
| Gene Symbol | CASP9 | ||||||||||||||||||||||||
| Gene Name | caspase-9 | ||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000002472 | ||||||||||||||||||||||||
| Encoded Proteins |
caspase 9, apoptosis-related cysteine peptidase
|
||||||||||||||||||||||||
| Protein Structure | |||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132906:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008] This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||
| Genomic Location | Chromosome 16:53250584-53273042 | ||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
TNFalpha pathway
BCR pathway
|
||||||||||||||||||||||||
| REACTOME |
AKT phosphorylates targets in the cytosol pathway
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
NOD1/2 Signaling Pathway pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
SMAC-mediated dissociation of IAP:caspase complexes pathway
SMAC binds to IAPs pathway
Activation of caspases through apoptosome-mediated cleavage pathway
Formation of apoptosome pathway
Role of DCC in regulating apoptosis pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
SMAC-mediated apoptotic response pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
Immune System pathway
Apoptotic factor-mediated response pathway
NGF signalling via TRKA from the plasma membrane pathway
Cytochrome c-mediated apoptotic response pathway
PI3K/AKT Signaling in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Disease pathway
Innate Immune System pathway
Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
SMAC-mediated dissociation of IAP:caspase complexes pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Activation of caspases through apoptosome-mediated cleavage pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Role of DCC in regulating apoptosis pathway
Cytochrome c-mediated apoptotic response pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
SMAC-mediated apoptotic response pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Regulation of Apoptosis pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
SMAC binds to IAPs pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
AKT phosphorylates targets in the cytosol pathway
NGF signalling via TRKA from the plasma membrane pathway
Formation of apoptosome pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Apoptotic factor-mediated response pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
Intrinsic Pathway for Apoptosis pathway
|
||||||||||||||||||||||||
| KEGG |
VEGF signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
Apoptosis pathway
Endometrial cancer pathway
Alzheimer's disease pathway
Small cell lung cancer pathway
Prostate cancer pathway
Pancreatic cancer pathway
p53 signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Parkinson's disease pathway
Huntington's disease pathway
Pathways in cancer pathway
Viral myocarditis pathway
Toxoplasmosis pathway
Endometrial cancer pathway
VEGF signaling pathway pathway
p53 signaling pathway pathway
Alzheimer's disease pathway
Colorectal cancer pathway
Small cell lung cancer pathway
Apoptosis pathway
Prostate cancer pathway
Non-small cell lung cancer pathway
Pancreatic cancer pathway
Parkinson's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
Pathways in cancer pathway
Viral myocarditis pathway
Toxoplasmosis pathway
|
||||||||||||||||||||||||
| INOH |
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
|
||||||||||||||||||||||||
| PID NCI |
Caspase Cascade in Apoptosis
Class I PI3K signaling events mediated by Akt
p75(NTR)-mediated signaling
HIV-1 Nef: Negative effector of Fas and TNF-alpha
|
||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||
| TrEMBL | E1BNU2 | ||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||
| Entrez Gene | 100140945 | ||||||||||||||||||||||||
| UniGene | Bt.66332 | ||||||||||||||||||||||||
| RefSeq | NM_001205504 XM_005217016 | ||||||||||||||||||||||||
| HUGO | HGNC:1511 | ||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||
| EMBL | DAAA02043259 DAAA02043260 DAAA02043261 | ||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||
| RNA Seq Atlas | 100140945 | ||||||||||||||||||||||||