InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SIGMAR1

Summary

InnateDB Protein

IDBP-687833.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIGMAR1

Protein Name

Sigma non-opioid intracellular receptor 1

Synonyms

OPRS1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020990

InnateDB Gene

IDBG-635955 (SIGMAR1)

Protein Structure

UniProt Annotation

Function

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus inner membrane {ECO:0000250}. Nucleus outer membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Lipid droplet {ECO:0000250}. Cell junction {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006869	lipid transport
GO:0043523	regulation of neuron apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030426	growth cone
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR006716 ERG2/sigma1 receptor-like

PFAM

PF04622

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DH7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538903

UniGene

Bt.714

RefSeq

NP_001029827

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT021620

GenPept

AAX46467