InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SIGMAR1

Summary

InnateDB Gene

IDBG-635955.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIGMAR1

Gene Name

Sigma non-opioid intracellular receptor 1

Synonyms

OPRS1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015804

Encoded Proteins

IDBP-687833

Sigma non-opioid intracellular receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147955:
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2008]
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:77345882-77348597

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020990

ENSBTAP00000020990

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006869	lipid transport
GO:0043523	regulation of neuron apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030426	growth cone
GO:0042995	cell projection

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000147955

View Gene Order

ENSMUSG00000036078

View Gene Order

Cross-References

SwissProt

Q58DH7

TrEMBL

UniProt Splice Variant

Entrez Gene

538903

UniGene

Bt.714

RefSeq

NM_001034655

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT021620

GenPept

AAX46467

RNA Seq Atlas

538903