InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GJB1

Summary

InnateDB Protein

IDBP-687910.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GJB1

Protein Name

Gap junction beta-1 protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027331

InnateDB Gene

IDBG-636024 (GJB1)

Protein Structure

UniProt Annotation

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007154	cell communication
GO:0015868	purine ribonucleotide transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000500 Connexin
IPR002267 Gap junction beta-1 protein (Cx32)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain

PFAM

PF00029
PF10582

PRINTS

PR00206
PR01138

PIRSF

SMART

SM00037
SM01089

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O18968

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281194

UniGene

Bt.516

RefSeq

NP_776494

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

X95311

GenPept

CAA64623