InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GJB1

Summary

InnateDB Gene

IDBG-636024.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GJB1

Gene Name

Gap junction beta-1 protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020512

Encoded Proteins

IDBP-687910

Gap junction beta-1 protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169562:
This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:84715936-84723342

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027331

ENSBTAP00000027331

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007154	cell communication
GO:0015868	purine ribonucleotide transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction