InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TYROBP

Summary

InnateDB Protein

IDBP-687944.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYROBP

Protein Name

TYRO protein tyrosine kinase-binding protein

Synonyms

dap12;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009652

InnateDB Gene

IDBG-636049 (TYROBP)

Protein Structure

UniProt Annotation

Function

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0042802	identical protein binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0002283	neutrophil activation involved in immune response
GO:0007229	integrin-mediated signaling pathway
GO:0016310	phosphorylation
GO:2001204	regulation of osteoclast development