Version 5.4
| Bos taurus Gene: TYROBP | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-636049.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | TYROBP | ||||||||||
| Gene Name | TYRO protein tyrosine kinase-binding protein | ||||||||||
| Synonyms | dap12 | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000007338 | ||||||||||
| Encoded Proteins |
TYRO protein tyrosine kinase-binding protein
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Mus musculus] Tyrobp impairs host defence during pneumococcal pneumonia at the primary site of infection by inhibiting phagocytosis by alveolar macrophages.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011600:
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 18:46779848-46782546 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
DAP12 interactions pathway
Immune System pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
Axon guidance pathway
Other semaphorin interactions pathway
Innate Immune System pathway
DAP12 signaling pathway
Semaphorin interactions pathway
Developmental Biology pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH |
RANKL pathway
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| REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Signal regulatory protein (SIRP) family interactions pathway
Other semaphorin interactions pathway
Developmental Biology pathway
Cell-Cell communication pathway
Semaphorin interactions pathway
Innate Immune System pathway
Axon guidance pathway
Adaptive Immune System pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
Signal regulatory protein (SIRP) family interactions pathway
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
Cell-Cell communication pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q95J79 | ||||||||||
| TrEMBL | B2BBK0 Q95KU7 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 282390 | ||||||||||
| UniGene | Bt.8939 | ||||||||||
| RefSeq | NM_174627 XM_005218906 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AJ419227 AJ419230 BC126797 DAAA02046954 EF118674 EF118675 EF118676 EF118677 EF118678 EF118679 EF118680 EF118681 EF118684 EF118685 EF118686 EF118687 EF118688 EF118689 EF118692 EF118693 EF118696 EF118697 EF118698 EF118699 EF118700 EF118702 EF118704 EF118705 EF118706 EF118707 EF118708 EF118711 EF118712 EF118714 EF118715 EF118716 EF118717 EF118718 EF118719 EF118720 EF118721 EF118722 EF118723 EF118724 EF118725 EF118726 EF118727 EF118728 EF118729 EF118730 EF118731 EF118732 EF118734 EF118735 | ||||||||||
| GenPept | AAI26798 ABO69943 ABO69944 ABO69945 ABO69946 ABO69947 ABO69948 ABO69949 ABO69950 ABO69953 ABO69954 ABO69955 ABO69956 ABO69957 ABO69958 ABO69961 ABO69962 ABO69965 ABO69966 ABO69967 ABO69968 ABO69969 ABO69971 ABO69973 ABO69974 ABO69975 ABO69976 ABO69977 ABO69980 ABO69981 ABO69983 ABO69984 ABO69985 ABO69986 ABO69987 ABO69988 ABO69989 ABO69990 ABO69991 ABO69992 ABO69993 ABO69994 ABO69995 ABO69996 ABO69997 ABO69998 ABO69999 ABO70000 ABO70001 ABO70003 ABO70004 CAD11669 CAD11672 | ||||||||||
| RNA Seq Atlas | 282390 | ||||||||||