InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRAP1

Summary

InnateDB Protein

IDBP-688006.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAP1

Protein Name

Heat shock protein 75 kDa, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026786

InnateDB Gene

IDBG-636097 (TRAP1)

Protein Structure

UniProt Annotation

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006950	response to stress
GO:1901856	negative regulation of cellular respiration

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF00183
PF02518
PF13581

PRINTS

PR00775

PIRSF

PIRSF002583

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References