InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MED12

Summary

InnateDB Protein

IDBP-688028.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED12

Protein Name

mediator complex subunit 12

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028464

InnateDB Gene

IDBG-636055 (MED12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0001843	neural tube closure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007507	heart development
GO:0014003	oligodendrocyte development
GO:0014044	Schwann cell development
GO:0019827	stem cell maintenance
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090245	axis elongation involved in somitogenesis

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

InterPro

IPR019035 Mediator complex, subunit Med12
IPR021989 Mediator complex, subunit Med12, catenin-binding
IPR021990 Mediator complex, subunit Med12, LCEWAV-domain

PFAM

PF09497
PF12144
PF12145

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-