InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKG

Summary

InnateDB Protein

IDBP-68819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKG

Protein Name

diacylglycerol kinase, gamma 90kDa

Synonyms

DAGK3; DGK-GAMMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000265022

InnateDB Gene

IDBG-68817 (DGKG)

Protein Structure

UniProt Annotation

Function

Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.

Subcellular Localization

Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.

Disease Associations

Tissue Specificity

Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding

Biological Process

GO:0007165	signal transduction
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0048666	neuron development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00609
PF00781
PF00036
PF13202
PF13405
PF00130

PRINTS

PIRSF

SMART

SM00045
SM00046
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49619