InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DGKG

Summary

InnateDB Gene

IDBG-68817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKG

Gene Name

diacylglycerol kinase, gamma 90kDa

Synonyms

DAGK3; DGK-GAMMA

Species

Homo sapiens

Ensembl Gene

ENSG00000058866

Encoded Proteins

IDBP-68819

diacylglycerol kinase, gamma 90kDa

IDBP-68821

diacylglycerol kinase, gamma 90kDa

IDBP-68823

diacylglycerol kinase, gamma 90kDa

IDBP-386359

diacylglycerol kinase, gamma 90kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:186105668-186362237

Strand

Reverse strand

Band

q27.3

Transcripts

ENST00000265022	ENSP00000265022
ENST00000344484	ENSP00000339777
ENST00000382164	ENSP00000371599
ENST00000447054
ENST00000437018	ENSP00000395526
ENST00000490452
ENST00000480809
ENST00000480933
ENST00000472506
ENST00000482566
ENST00000466466

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0048666	neuron development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022861

View Gene Order

ENSBTAG00000005091

Not yet available

Pathways

NETPATH

REACTOME

REACT_2202

Effects of PIP2 hydrolysis pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14797

Signaling by GPCR pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_604

Hemostasis pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa00561

Glycerolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.683449 Hs.692980

RefSeq

NM_001080744 NM_001080745 NM_001346

HUGO

OMIM

CCDS

CCDS3274 CCDS43181 CCDS43182

HPRD

03510

IMGT

EMBL

GenPept

RNA Seq Atlas