InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DGKA

Summary

InnateDB Protein

IDBP-688357.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKA

Protein Name

Diacylglycerol kinase alpha

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000038002

InnateDB Gene

IDBG-636422 (DGKA)

Protein Structure

UniProt Annotation

Function

Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

PFAM

PF00609
PF00781
PF00036
PF13202
PF13405
PF00130

PRINTS

PIRSF

SMART

SM00045
SM00046
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A0JN54