InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DGKA

Summary

InnateDB Gene

IDBG-636422.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKA

Gene Name

Diacylglycerol kinase alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004018

Encoded Proteins

IDBP-688357

Diacylglycerol kinase alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065357:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:57678063-57699615

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000038186

ENSBTAP00000038002

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction