Version 5.4
Bos taurus Protein: BCAR3
Summary
InnateDB Protein IDBP-688369.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAR3
Protein Name breast cancer anti-estrogen resistance protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055991
InnateDB Gene IDBG-636444 (BCAR3)
Protein Structure
UniProt Annotation
Function May act as an adapter protein and couple activated growth factor receptors to signaling molecules that regulate src kinase activity and promote cell migration. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain
PFAM PF00017
PF14633
PF00617
PRINTS PR00401
PIRSF
SMART SM00252
SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DL5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506231
UniGene Bt.65543
RefSeq NP_001019654
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105366 BT021582
GenPept AAI05367 AAX46429

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca