Version 5.4
Bos taurus Gene: BCAR3
Summary
InnateDB Gene IDBG-636444.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAR3
Gene Name Breast cancer anti-estrogen resistance protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003245
Encoded Proteins
IDBP-688369
breast cancer anti-estrogen resistance protein 3
IDBP-688370
breast cancer anti-estrogen resistance protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137936:
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49850609-50069722
Strand Forward strand
Band
Transcripts
ENSBTAT00000063777 ENSBTAP00000055991
ENSBTAT00000004211 ENSBTAP00000004211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137936
View Gene Order
ENSMUSG00000028121
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt Q58DL5
TrEMBL
UniProt Splice Variant
Entrez Gene 506231
UniGene Bt.20613 Bt.65543
RefSeq NM_001024483 XM_005204269 XM_005204270
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105366 BT021582
GenPept AAI05367 AAX46429
RNA Seq Atlas 506231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca